PHOTOMECHANICAL WAVE-DRIVEN DELIVERY OF SIRNAS TARGETING INTERMEDIATE FILAMENT PROTEINS PROMOTES FUNCTIONAL RECOVERY AFTER SPINAL CORD INJURY IN RATS.

The formation of glial scars after spinal cord injury (SCI) is one of the factors inhibiting axonal regeneration.Glial scars are mainly composed of reactive astrocytes overexpressing intermediate filament (IF) proteins such as glial fibrillary acidic protein (GFAP) and vimentin.In the current study, we delivered small interfering RNAs (siRNAs) targ

Androgen deprivation therapy (ADT) is a common treatment for recurrent prostate cancer (PC).However, after a certain period of responsiveness, ADT resistance occurs virtually in all patients and the disease progresses to lethal metastatic castration-resistant prostate cancer (mCRPC).Aberrant expression and function of the epigenetic modifiers EZH2

A 49 year-old man with medical history of diabetes type 2, who presented to the ophthalmology clinic for decreased vision.His most recent hemoglobin A1c was 11.4%.His intraocular pressures were 19 mmHg OD and 35 mmHg OS.Posterior segment exam showed severe proliferative diabetic retinopathy in both eyes.Neovascularization of the iris (NVI), also kn

Abstract Background The early diagnosis of cancer is of crucial importance and a key prognostic factor.Cancer-associated retinopathy (CAR) can be symptomatic prior to other manifestations directly related to malignant tumors.The aim of this study was to show that, in selected cases, ophthalmic findings are consistent Normally Open Thermal Cutout en

This is Part 1 of an updated follow-up review of a World Allergy Organization (WAO) position paper published in 2012 on the diagnosis and treatment of urticaria and angioedema.Since 2012, there have been advances in the understanding of the pathogenesis of chronic urticaria, and greater experience with the use of biologics, such as omalizumab, in p